Inclusion (Minimum requirements)

Aged 18 years and above

Unresectable (cannot be surgically removed or fully removed/resected), locally advanced or metastatic renal cell carcinoma with a primary clear cell component.

You have had previous immunotherapy treatment (anti-PD-1 or anti-PD-L) but your cancer has progressed or has not responded to the treatment

Exclusion (Generally not allowed)

Received prior treatment with a HIF-2α inhibitor or cabozantinib.

Have had another active cancer within the previous year except for locally curable cancers that have been apparently cured.

Uncontrolled or poorly controlled hypertension, as defined by a sustained blood pressure > 140/90 mm Hg on more than three antihypertensives

Please note this is not a complete list of inclusion and exclusion criteria. If you appear suitable based on the above criteria, the next step will be a pre-screening call with our oncology nursing team.

• unresectable, locally advanced, or metastatic renal cell carcinoma with a primary clear cell component